Efficacy and Safety of Sitagliptin Versus Glipizide in PatientsWith Type 2 Diabetes andModerate-to-Severe Chronic Renal Insufficiency
تاریخ : ۱۳۹۳/۰۷/۲۲ /
تعداد بازدید : ۲۳۰
Abstract
Objective
Patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease have an increased risk ofmicro- and macrovascular disease, but limited options for antihyperglycemic therapy. We compared the efficacy and safety of sitagliptin with glipizide in patients with T2DM and moderate-to-severe chronic renal insufficiency and inadequate glycemic control.
Research design and Methods
Patients (n = 426) were randomized 1:1 to sitagliptin (50 mg every day [q.d.] for moderate renal insufficiency and 25 mg q.d. for severe renal insufficiency) or glipizide (2.5 mg q.d., adjusted based on glycemic control to a 10-mg twice a day maximum dose). Randomization was stratified by: 1) renal status (moderate or severe renal insufficiency); 2( history of cardiovascular disease; and 3) history of heart failure.
Results
At week 54, treatment with sitagliptin was noninferior to treatment with glipizide in A1C change from baseline (20.8 vs. 20.6%; between-group difference 20.11%; 95% CI 20.29 to 0.06) because the upper bound of the 95% CI was less than the prespecified noninferiority margin of 0.4%. There was a lower incidence of symptomatic hypoglycemia adverse events (AEs) with sitagliptin versus glipizide (6.2 and 17.0%, respectively; P = 0.001) and a decrease in body weight with sitagliptin (20.6 kg) versus an increase (1.2 kg) with glipizide (difference, 21.8 kg; P , 0.001). The incidence of gastrointestinal AEs was low with both treatments.
Conclusions
In patients with T2DM and chronic renal insufficiency, sitagliptin and glipizide provided similar A1C-lowering efficacy. Sitagliptin was generally well-tolerated, with a lower risk of hypoglycemia and weight loss versus weight gain, relative to glipizide.
آخرین مقالات
Phase III Dose-Comparison Study of Glatiramer Acetate for Multiple Sclerosis
۱۴۰۲/۰۳/۱۶
تعداد بازدید : ۳۷۵
دانستنی های مفید در خصوص حساسیت دارویی
۱۳۹۴/۰۷/۲۱
تعداد بازدید : ۲۹۰
دلایل و درمان سرگیجه
۱۳۹۴/۰۷/۲۱
تعداد بازدید : ۱۲۱۴
Efficacy of deferasirox in reducing and preventing cardiac iron overload in β-thalassemia
۱۳۹۴/۰۳/۰۹
تعداد بازدید : ۳۲۳
The Effectiveness of Dimethyl Fumarate Monotherapy in the Treatment of Relapsing-Remitting Multiple Sclerosi
۱۳۹۴/۰۲/۱۴
تعداد بازدید : ۴۲۷
Pharmacology and clinical efficacy of dimethyl fumarate (BG-12) for treatment of relapsing–remitting multiple sclerosis
۱۳۹۴/۰۲/۱۴
تعداد بازدید : ۴۳۳
نظرات کاربران