66801075-83 info@osvahpharma.com

Effects of Moderate Weight Loss and Orlistat on Insulin Resistance, Regional Adiposity, and Fatty Acids in Type 2 Diabetes

تاریخ : ۱۳۹۳/۰۴/۱۰ / تعداد بازدید : ۲۸۱
Abstract
OBJECTIVE:
Moderate weight loss is recommended for overweight and obese patients with type 2 diabetes, and conjunctive use of weight loss medication has been advocated. The current study examined weight loss– dependent and –independent effects of the intestinal lipase inhibitor orlistat at 6 months of treatment, using behavioral intervention (Int) combined with randomized, double-blinded, placebo (P)-controlled treatment with orlistat (O).
RESEARCH DESIGN AND METHODS :
Metabolic control, insulin sensitivity (IS),regional fat distribution, and fat content in liver and muscle were measured in 39 volunteers with type 2 diabetes in whom all antidiabetic medication was withdrawn 1 month preceding randomization. Weight loss was equivalent in the IntO and IntP groups, respectively (10.3 1.3 vs. 8.9  1.1%), and there were identical decreases in visceral adipose tissue (VAT), fat mass (FM), thigh adiposity, and hepatic steatosis.
RESULTS: 
Weight loss resulted in substantial improvement (P0.001) in HbA1c (1.6 0.3 vs.1.00.4%; NS between groups). IS improved significantly more with orlistat (2.2 0.4 vs. 1.2  0.4 mg  min–1  kg–1 fat-free mass [FFM]; P  0.05), and plasma free fatty acid (FFA) levels were strongly correlated with IS (r  0.56; P  0.001). Orlistat caused greater reductions in fasting plasma FFA (–154  22 vs. –51  33 mol/l; P  0.05), insulinsuppressed FFA (–119  23 vs. –87  34 mol/l; P  0.05), and fasting plasma glucose (FPG;629 vs.328 mg/dl; P0.02). Changes in HbA1c were correlated with IS (r 0.41; P  0.01) but not with weight loss per se. 
CONCLUSIONS:
At equivalent weight loss, conjunctive use of orlistat resulted in greater improvement in FFA levels and IS.
آخرین مقالات

Phase III Dose-Comparison Study of Glatiramer Acetate for Multiple Sclerosis

۱۴۰۲/۰۳/۱۶ تعداد بازدید : ۳۷۶

دانستنی های مفید در خصوص حساسیت دارویی

۱۳۹۴/۰۷/۲۱ تعداد بازدید : ۲۹۰

دلایل و درمان سرگیجه

۱۳۹۴/۰۷/۲۱ تعداد بازدید : ۱۲۱۶

Efficacy of deferasirox in reducing and preventing cardiac iron overload in β-thalassemia

۱۳۹۴/۰۳/۰۹ تعداد بازدید : ۳۲۴

The Effectiveness of Dimethyl Fumarate Monotherapy in the Treatment of Relapsing-Remitting Multiple Sclerosi

۱۳۹۴/۰۲/۱۴ تعداد بازدید : ۴۲۸

Pharmacology and clinical efficacy of dimethyl fumarate (BG-12) for treatment of relapsing–remitting multiple sclerosis

۱۳۹۴/۰۲/۱۴ تعداد بازدید : ۴۳۴
نظرات کاربران
دیدگاه